Keywords
Abstract
Comparative assessment of endothelial dysfunction indicators in patients with IMTV depending on the form of the disease and the characteristics of its course. Material and methods. We examined 140 patients with BMI at the age of 18-62 years. All patients, depending on the clinical manifestations of the disease, were subdivided into 4 groups: 1st - 32 patients with skin, 2nd - 84 patients with skin-articular, 3rd - 12 patients with mixed skin-articular and abdominal and 4th group - 12 patients with generalized skin-articular and renal forms of IMTV. The control group consisted of 20 conditionally healthy individuals. The indices of the vascular-platelet, coagulation link of hemostasis, the anticoagulant system were assessed according to generally accepted methods. Endothelial dysfunction was assessed by the level of endothelin 1 (ET-1), von Willebrand factor (vWF), thrombomodulin and adhesion molecules (sICAM-1)) by enzyme immunoassay. The digital material was processed by the method of variation statistics. Results. The study of the vascular-platelet link of hemostasis in patients with IMTT showed a tendency to develop moderate thrombocytosis and an increase in their thrombogenic activity. The study of three phases of the coagulation link of hemostasis indicated pronounced hypercoagulation in all groups. The dynamics of changes in hemostasiological parameters showed their relationship with the activity and severity of IMTV. A pronounced endothelial dysfunction was revealed, manifested by an increase in the content of ET-1, vWF, sICAM-1, and thrombomodulin in the blood plasma. The severity of these changes is minimal in the cutaneous form of the disease and sharply increases in its generalized form.. Output: In patients with IMTV, depending on the form of the disease, dysfunction of endotheliocytes of microvessels develops with inhibition of anticoagulant and increased procoagulant components.