Keywords
Abstract
The features of the uninucleid genetic polymorphism IL6 (C174G) in purulent-inflammatory diseases of the middle ear in Uzbekistan were studied. Polymorphisms of the IL6 gene (C174G) were investigated by analyzing DNA samples by PCR in real time. The results of the study made it possible to establish among carriers of the heterozygous C/ G genotype an unexpressed tendency to increase the risk of purulent-inflammatory diseases of the middle ear of the lung course by 1.5 times (χ 2=1.1; P = 0.3) compared with the control and 2.4 times (χ2 = 3.8; P = 0.1) compared with the moderate and severe course of the disease, as well as among carriers of the mutant genotype G / G tend to increase the likely risk of the formation of purulent-inflammatory diseases of the middle ear with moderate and severe course compared with the control by 2.2 times (χ2 =1.5; P=0.3). The findings indicate a possible contribution of the polymorphic IL6 (C174G) gene to the mechanisms of increased risk of formation of purulent-inflammatory diseases of the middle ear in Uzbekistan.