Keywords
osteoarthritis, pro-inflammatory cytokines, interleukin-1β, interleukin-6, metabolic syndrome
Abstract
This article summarizes the current understanding of the role of cytokines in the pathogenesis of osteoarthritis (OA). An imbalance between proinflammatory and anti-inflammatory cytokines in the joint tissues contributes to the development of inflammation and cartilage damage, which leads to progressive joint degeneration. This research studied the role of pro-inflammatory cytokines in OA and the impact on the course of disease against the background of metabolic syndrome.