Keywords
diabetes mellitius, arterial hypertension, podocyt, nephropathy, comorbidity, renal functional reserves
Abstract
Obesity-associated kidney disease with diabetes develops when several metabolic and hemodynamic factors interact, activating common intracellular signals, which, in turn, cause the production of cytokines and growth factors that form kidney failure. The mechanisms underlying glomerular hyperfiltration in the presence of obesity are widely discussed in the literature cardiovascular diseases, obesity, type II diabetes, and kidney dysfunction are becoming more and more pandemics of the 21st century. In recent years, the main cause of renal dysfunction is not its primary disease, but hypertension , it means essential arterial hypertension and diabetes mellitius.