Keywords
Abstract
The purpose of the study is to study the role of a renin-angiotensin-aldosterone system in the progression of type 2 diabetes mellitus (DM2), associated with chronic heart failure (CHF)
Material and research methods. For the period of 2015-2022, 185 patients were determined and selected as an object of study according to the materials of their treatment into Andijan medical and preventive institutions from 30 years and older.
Patients were distributed to 3 groups:
1 group - these are patients with DM 2 +CHF - 65 patients,
Group 2 - these are patients with DM 2without CHF - 60 patients,
Group 3 - these are patients with CHF without DM 2 - 60 patients
Results. To assess the diagnostic significance of this marker, we conducted a correlation analysis of the connection of other indicators affecting the level of aldosterone in blood serum patients with diabetes 2 in combination with heart failure. The correlation analysis conducted by us showed the presence of a direct connection between medium force between the indicators of aldosterone and the age of patients suffering from DM 2 in combination with CHF. Thus, in patients with DM 2 with heart failure, an increase in these markers is the most important predictors of an unfavorable forecast for the development of complications up to mortality.
Conclusions. 1. In the study of aldosterone, increased indicators were revealed in all groups, while in patients with heart failure, the indicators are significantly higher than in the group of patients with DM 2In the group of patients with DM2 in combination with CHF, the indicators were the highest, statistically distinguished from indicators of patients with diabetes 2 (p <0.001) and inaccurate in comparison with the CHF group (P> 0.05).
2. Renin's levels in groups were significantly higher than the upper limit of the norm lying. At the same time, in the group of DM 2+CHF, the rates of plasma renin statistically reliably exceeded the indicators in the group of patients with isolated diabetes (p <0.05).
3. The results of studies of the interconnection of the plasma level of aldosterone with various clinical characteristics (age, BMI, FV LV, SKF, blood glucose level, HBA1C) of patients with isolated D2 and heart failure are extremely contradictory, and when combined with these pathologies, are practically absent.