Keywords
Abstract
Assisted reproductive technology (ART) has been an important therapy and the go-to option for many infertile couples who want to have children. Although the pregnancy rate with ART in several fertility centers is stable at around 40%, the rate of carrying a child home is still 20–30%, one of the important reasons is the high rate of early spontaneous abortions [1,2,10]. First trimester miscarriages occur in 10-15% of all clinically confirmed pregnancies, with fetal chromosomal abnormalities being the most common cause of spontaneous miscarriages, accounting for approximately 60% of these pregnancy losses [3,4,5]. However, the frequency of early spontaneous abortions in patients after ART ranges from 22% to 63%. Failure of ART treatment is associated with many factors, genetic defects, especially embryonic chromosomal abnormalities, are one of the main causes of spontaneous miscarriage in the first trimester [6,7,8,9].
Relevance. Infertility is defined as the inability to conceive a child after one year of proper intercourse in terms of timeliness, technique and without the use of contraceptive methods. About 10-15% of married couples suffer from this problem [1], [2]. Many infertile couples, especially in some tribal communities, have faced serious personal, family, social and economic problems, having lost the opportunity to have a child [3]. In recent years, there have been many scientific and technical advances in the treatment of infertility. Some people who previously struggled with infertility now have a better therapeutic chance [4]. However, the success rate of such methods has not shown significant progress, despite their dual use over the past decade [5].
Although numerous and few studies have been conducted so far to identify factors associated with miscarriage, comprehensive and more accurate studies are required to identify all suspected risk factors. Therefore, the present study aims to evaluate the effect of 19 risk factors associated with miscarriage in pregnant women receiving ART.