Keywords
rheumatoid arthritis, internal factors, genetic and environmental factors, human leucocyte antigen (HLA)-D MHC locus, hereditary predisposition
Abstract
The causes of rheumatoid arthritis (RA) are largely unknown. However, RA is most likely a multifactorial disease with contributions from genetic and environmental factors. The search for genes affecting RA was carried out both in human and experimental model materials. Both types of studies confirmed the polygenic inheritance of the disease. This article deals with the pathogenesis of rheumatoid arthritis of molecular genetic origin.