Keywords
Abstract
The features of the polymorphism of the CYP1A1 gene (Ile462Val) among patients with HPVLO and healthy people in Uzbekistan were studied. The polymorphism of the CYP1A1 gene (Ile462Val) was assessed by analyzing DNA samples by setting the polymerase chain reaction (PCR) in Real Time mode .
Ile462Val polymorphism in the CYP1A1 gene among the studied groups of patients with HPVLO showed that the functionally unfavorable minor allelic variant G and the variant of the G / G genotype occur with a relatively high frequency, exceeding their values in the group of healthy individuals. More frequent carriage of these variants may indicate a trend towards an increased risk of developing an isolated cleft palate ( Q 35; for the allele G - χ 2 =1.8; P=0.2 and genotype G / G - χ 2 \u003d 2.7; P=0.1 ) and lips ( Q 36; for allele G - χ 2 =3.4; P=0.1 and genotype G / G χ 2 \u003d 1.4; P=0.3 ), which means that the studied Ile462Val polymorphism in the CYP1A1 gene may have a certain contribution to the mechanisms of the formation of these pathologies in Uzbekistan.