Keywords
Abstract
Studies have shown that the gastrointestinal form of food allergy in children is often combined with diseases of the gastrointestinal tract associated with Helicobacter pylori infection. The aim of the study was to study the relationship between the immunological and biochemical parameters of blood and saliva in the gastrointestinal form of food allergy in children, depending on the Helicobacter pylori infection. To study the effect of concomitant pathology on the course of food allergy and non-invasive diagnostic methods, 63 patients from 3 to 10 years of age with gastrointestinal allergy were examined. For early non-invasive diagnosis and differentiation of gastrointestinal allergy in children, depending on the Helicobacter pylori infection, it is advisable to determine the concentration of IgE in saliva and diastasis in urine. The authors conducted a study of immunological and biochemical parameters in biological media in the gastrointestinal form of food allergy in children. The study proved an increase in the concentration of IL-8, TNF-α, IgE and a decrease in sIgA in saliva in patients with gastrointestinal allergy, regardless of the association with Helicobacter pylori; it was proved that the quantitative insufficiency of CD8+ T cells in Helicobacter pylori-associated gastrointestinal allergy is an informative factor in the development of chronic diseases of the gastrointestinal tract with a high risk of developing an autoimmune mechanism. It was also revealed that IgE in saliva and urine diastasis are informative indicators of early and non-invasive diagnosis, differentiation of gastrointestinal allergy in children, depending on the infection with Helicobacter pylori. In patients with Helicobacter pylori-associated gastrointestinal allergy, a strong positive relationship of Helicobacter pylori infection with saliva IgE and urine diastasis was established, which was not typical for gastrointestinal allergies without Helicobacter pylori infection.