Abstract
To study in detail the pathogenetic aspects of COVID-19, which will allow us to understand the genesis of the development of the disease, as well as their complications. This will improve the medical care provided to this category of patients. The relationship between triggering the release of pro-inflammatory cytokines with the development of infiltration in endothelial cells, microvascular dysfunction, and an increase in respiratory failure is presented. Based on the literature review data, the article describes the genesis of the trigger development of respiratory pathology, as well as multiple organ failure, which contribute to the progression of COVID-19.