Keywords
missense mutation Gly102Ser of the LHB gene, male infertility, Allele Frequency Database, luteinizing hormone
Abstract
The luteinizing hormone ß-chain (LHB) gene is localized on chromosome 11p13 and contains 3 exons. The analysis of the Gly102Ser missense mutation of the LHB gene in the formation of male infertility was carried out. The study was conducted on a sample of 140 patients with various clinical forms of male infertility and 155 conditionally healthy fertile men. The obtained molecular genetic data on the G1502A marker of the LHB gene are representative. The data will complement the international database (Allele Frequency Database) on the frequency of the mutation variant G1502A of the LHB gene for various populations and ethnic groups of the countries of the world.