Keywords
Abstract
The role of polymorphisms was analyzed Ile462Val of the CYP1A1 gene, C6310T of the CYP1A1 gene, G681A of the CYP2C19 gene, and G636A of the CYP2C19 gene in the formation of male infertility. The work was carried out on samples of 140 patients with various clinical manifestations of male infertility and 155 conditionally healthy fertile Uzbek men. It was found that the proportion of carriage of unfavorable allelic variants of the Ile462Val polymorphisms of the CYP1A1 gene and G636A of the CYP2C19 gene among patients was significantly higher than in individuals without reproductive system disorders, and these loci were associated with an increased risk of developing infertility in men. The results of the analysis of the C6310T polymorphisms of the CYP1A1 gene and G681A of the CYP2C19 gene did not reveal any significant differences in the distribution of allele and genotype frequencies between the studied samples.