Keywords
Abstract
The article presents the results of an epidemiological study of esophageal atresia in the structure of congenital malformations. These results are based on a five-year monitoring of congenital malformations in 13 regions of the Republic of Uzbekistan for the period 2015-2020. During the study period, the overall frequency of AP with interregional difference was 0.62 per 10000 (95% CI 0.49-0.64) or 1 in 16129 newborns and remained stable over time. Fistulous forms occurred in 96.6%, non-fistulous forms in 3.4% of children. Among newborns with AP, congenital heart defects were observed in 58%, gastrointestinal tract in 25.9%, urinary system in 17.3%, musculoskeletal system in 7.7% of patients. CNS defects and other disorders occurred in 4.81% of cases. In terms of relative risk (RR), the risk of having AP was high in newborns (RR = 1.94; 95% CI 1.47–2.56). The maximum relative risk was observed in newborns with low birth weight (RR=1.25; 95% CI 0.96 - 1.64).