Keywords
Abstract
It is known that the frequency of aseptic necrosis of the femoral head increased significantly during the COVID-19 pandemic. The use of corticosteroid drugs in the acute phase of COVID-19, chronic hypercoagulopathy caused by COVID-19, lifestyle (pernicious habits) of patients, genetic predisposition are of great importance in the development of the disease. It is known that microvascular circulatory disorders are considered an important pathogenetic factor in the development of aseptic necrosis. Therefore, thrombophilia genes are designed to study polymorphisms in patients with aseptic necrosis, such as the gene MTHFR A1298C (rs1801131), C677T (rs1801133), the gene MTR A2756G (rs1805087) and the gene MTRR A66G (rs1801394), in the Uzbek population. These polymorphisms were studied to determine the significance of minor alleles in the development of COVID-19-related disease. The selection of people prone to the development of this disease was carried out, and the combined influence of additional exogenous factors, such as negative habits, was studied. By selecting individuals who are carriers of the minor allele, special preventive and therapeutic measures can be carried out in order to reduce the frequency of aseptic necrosis associated with COVID-19, as well as a possible reduction in the incidence rate.