Keywords
Abstract
Goal. To compare changes in bone, metabolic and anthropometric parameters in young women with hypergonadotropic amenorrhea (premature ovarian failure [POF], complete androgen insensitivity syndrome [CAIS] with removed gonads), undergoing various HT (transdermal estradiol [TE], oral estradiol valerate [OEV], oral ethinyl estradiol [OEE] with or without progestin) or without therapy. Methods. A pilot cohort study based on prospectively collected data. Bone density, body composition and anthropometric parameters were assessed in 40 young women. Results. At time t0, only 5% of patients had normal bone mineral density (BMD) in all bone regions, while 75% and 20% had osteopenia or osteoporosis, respectively, in at least one bone region. Control densitometry (t1) was performed 22.1 ± 9.2 months later. Lumbar and femoral BMD increased over time in the treatment groups with a significant time-treatment interaction effect (p = 0.004 and p = 0.025, respectively). Conclusions. These preliminary data suggest that estradiol is administered both transdermally and orally in young women with hypergonadotropic amenorrhea.