Abstract
A Epizootological manifestations of the plague in 2011-2020 were registered on the territory of 11 states. Data on the Central Part of the Kyzylkum natural desert plague outbreak indicate a reduction in major and minor plague carriers. In the conditions of mountainous and high-altitude landscapes, the impact of modern climate warming on the state of parasitic systems of the mountain and high-altitude natural plague foci is less pronounced. The epizootic potential of many autonomous biological principles of the gopher and sandy type has significantly decreased in the current century.