Abstract
Objective: to study the effect of endogenous intoxication on the liver in patients
with diabetes mellitus (DM) complicated by purulent - necrotic soft tissue lesion (PNSFL).
Materials and methods: 110 patients with diabetes mellitus complicated by purulentnecrotic soft tissue lesion and the effect of endotoxicosis on the functional state of the liver
were examined in the intensive care unit, with optimization of correction of liver failure.
Patients were divided into 2 groups: 52 (control), 58 (study), which, in addition to
traditional therapy, included hepatoprotectors and drugs that stop transaminase activity.
Conclusions. The inclusion of hepatoprotectors, antioxidants and drugs blocking transaminase
activity in complex therapy is pathogenetically justified and optimizes the outcomes of such
a formidable complication of diabetes as PNSFL.